Efficacy of co-administered diethylcarbamazine and albendazole against adult Wuchereria bancrofti
Identifieur interne : 007A78 ( Main/Exploration ); précédent : 007A77; suivant : 007A79Efficacy of co-administered diethylcarbamazine and albendazole against adult Wuchereria bancrofti
Auteurs : Gerusa Dreyer [Brésil] ; David Addiss [États-Unis] ; John Williamson [États-Unis] ; Joaquim Nor Es [Brésil]Source :
- Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2006-12.
English descriptors
- KwdEn :
Abstract
Although diethylcarbamazine (DEC) and albendazole are recommended to interrupt transmission of Wuchereria bancrofti, little is known about the macrofilaricidal effect of this drug combination. Forty-seven men with W. bancrofti infection were randomly assigned to receive a single dose of either DEC alone (6 mg/kg) (n = 25) or a combination of DEC (6 mg/kg) and albendazole (400 mg) (n = 22). Physical examinations for scrotal nodules (resulting from worm death) and ultrasound examinations (to detect living adult worms) were performed before treatment and 7, 14, 30, 45, 60, 90, 180, 270 and 360 days after treatment. Blood was examined for microfilariae before and 30 days and 360 days after treatment. Seven days post treatment, intrascrotal nodules were detected at the site of 21 (46.7%) adult worm nests in men who received DEC alone compared with 2 (6.1%) sites in men who received DEC and albendazole (P = 0.002). One year after treatment, 10 (22.2%) original adult worm nests remained detectable by ultrasound among men who received DEC alone compared with 18/32 (56.3%) nests among men who received both drugs (P = 0.016). Microfilaraemia prevalence and density decreased to a similar extent in both groups. Addition of albendazole appeared to decrease the macrofilaricidal effect of DEC against W. bancrofti, with no detectable enhancement in microfilarial suppression.
Url:
DOI: 10.1016/j.trstmh.2006.04.006
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000394
- to stream Istex, to step Curation: 000394
- to stream Istex, to step Checkpoint: 001562
- to stream Main, to step Merge: 007C71
- to stream Main, to step Curation: 007A78
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Efficacy of co-administered diethylcarbamazine and albendazole against adult Wuchereria bancrofti</title><author><name sortKey="Dreyer, Gerusa" sort="Dreyer, Gerusa" uniqKey="Dreyer G" first="Gerusa" last="Dreyer">Gerusa Dreyer</name></author><author><name sortKey="Addiss, David" sort="Addiss, David" uniqKey="Addiss D" first="David" last="Addiss">David Addiss</name></author><author><name sortKey="Williamson, John" sort="Williamson, John" uniqKey="Williamson J" first="John" last="Williamson">John Williamson</name></author><author><name sortKey="Nor Es, Joaquim" sort="Nor Es, Joaquim" uniqKey="Nor Es J" first="Joaquim" last="Nor Es">Joaquim Nor Es</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:08BDB13FA4F7E3873CC5F56ADC64278EFCC04AA2</idno><date when="2006" year="2006">2006</date><idno type="doi">10.1016/j.trstmh.2006.04.006</idno><idno type="url">https://api.istex.fr/document/08BDB13FA4F7E3873CC5F56ADC64278EFCC04AA2/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000394</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000394</idno><idno type="wicri:Area/Istex/Curation">000394</idno><idno type="wicri:Area/Istex/Checkpoint">001562</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001562</idno><idno type="wicri:doubleKey">0035-9203:2006:Dreyer G:efficacy:of:co</idno><idno type="wicri:Area/Main/Merge">007C71</idno><idno type="wicri:Area/Main/Curation">007A78</idno><idno type="wicri:Area/Main/Exploration">007A78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Efficacy of co-administered diethylcarbamazine and albendazole against adult Wuchereria bancrofti</title><author><name sortKey="Dreyer, Gerusa" sort="Dreyer, Gerusa" uniqKey="Dreyer G" first="Gerusa" last="Dreyer">Gerusa Dreyer</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>NEPAF, Hospital das Clínicas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego s/n, Cidade Universitária, CEP 50740-900, Recife PE</wicri:regionArea><placeName><region type="state">Pernambuco</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Centro do Pesquisas Aggeu Magalhaes, FIOCRUZ, Recife PE</wicri:regionArea><placeName><region type="state">Pernambuco</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Brésil</country></affiliation></author><author><name sortKey="Addiss, David" sort="Addiss, David" uniqKey="Addiss D" first="David" last="Addiss">David Addiss</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Williamson, John" sort="Williamson, John" uniqKey="Williamson J" first="John" last="Williamson">John Williamson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA</wicri:regionArea><placeName><region type="state">Géorgie (États-Unis)</region></placeName></affiliation></author><author><name sortKey="Nor Es, Joaquim" sort="Nor Es, Joaquim" uniqKey="Nor Es J" first="Joaquim" last="Nor Es">Joaquim Nor Es</name><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>NEPAF, Hospital das Clínicas, Universidade Federal de Pernambuco, Av. Prof. Moraes Rego s/n, Cidade Universitária, CEP 50740-900, Recife PE</wicri:regionArea><placeName><region type="state">Pernambuco</region></placeName></affiliation><affiliation wicri:level="2"><country xml:lang="fr">Brésil</country><wicri:regionArea>Departmento de Cirurgia, Hospital das Clínicas, Universidade Federal de Pernambuco, Recife PE</wicri:regionArea><placeName><region type="state">Pernambuco</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Transactions of The Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">Trans R Soc Trop Med Hyg</title><idno type="ISSN">0035-9203</idno><idno type="eISSN">1878-3503</idno><imprint><publisher>Royal Society of Tropical Medicine and Hygiene</publisher><date type="published" when="2006-12">2006-12</date><biblScope unit="volume">100</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1118">1118</biblScope><biblScope unit="page" to="1125">1125</biblScope></imprint><idno type="ISSN">0035-9203</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0035-9203</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Albendazole</term><term>Diethylcarbamazine</term><term>Lymphatic filariasis</term><term>Macrofilaricidal effect</term><term>Microfilaria</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Although diethylcarbamazine (DEC) and albendazole are recommended to interrupt transmission of Wuchereria bancrofti, little is known about the macrofilaricidal effect of this drug combination. Forty-seven men with W. bancrofti infection were randomly assigned to receive a single dose of either DEC alone (6 mg/kg) (n = 25) or a combination of DEC (6 mg/kg) and albendazole (400 mg) (n = 22). Physical examinations for scrotal nodules (resulting from worm death) and ultrasound examinations (to detect living adult worms) were performed before treatment and 7, 14, 30, 45, 60, 90, 180, 270 and 360 days after treatment. Blood was examined for microfilariae before and 30 days and 360 days after treatment. Seven days post treatment, intrascrotal nodules were detected at the site of 21 (46.7%) adult worm nests in men who received DEC alone compared with 2 (6.1%) sites in men who received DEC and albendazole (P = 0.002). One year after treatment, 10 (22.2%) original adult worm nests remained detectable by ultrasound among men who received DEC alone compared with 18/32 (56.3%) nests among men who received both drugs (P = 0.016). Microfilaraemia prevalence and density decreased to a similar extent in both groups. Addition of albendazole appeared to decrease the macrofilaricidal effect of DEC against W. bancrofti, with no detectable enhancement in microfilarial suppression.</div></front></TEI><affiliations><list><country><li>Brésil</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Pernambuco</li></region></list><tree><country name="Brésil"><region name="Pernambuco"><name sortKey="Dreyer, Gerusa" sort="Dreyer, Gerusa" uniqKey="Dreyer G" first="Gerusa" last="Dreyer">Gerusa Dreyer</name></region><name sortKey="Dreyer, Gerusa" sort="Dreyer, Gerusa" uniqKey="Dreyer G" first="Gerusa" last="Dreyer">Gerusa Dreyer</name><name sortKey="Dreyer, Gerusa" sort="Dreyer, Gerusa" uniqKey="Dreyer G" first="Gerusa" last="Dreyer">Gerusa Dreyer</name><name sortKey="Nor Es, Joaquim" sort="Nor Es, Joaquim" uniqKey="Nor Es J" first="Joaquim" last="Nor Es">Joaquim Nor Es</name><name sortKey="Nor Es, Joaquim" sort="Nor Es, Joaquim" uniqKey="Nor Es J" first="Joaquim" last="Nor Es">Joaquim Nor Es</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Addiss, David" sort="Addiss, David" uniqKey="Addiss D" first="David" last="Addiss">David Addiss</name></region><name sortKey="Williamson, John" sort="Williamson, John" uniqKey="Williamson J" first="John" last="Williamson">John Williamson</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 007A78 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 007A78 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:08BDB13FA4F7E3873CC5F56ADC64278EFCC04AA2
|texte= Efficacy of co-administered diethylcarbamazine and albendazole against adult Wuchereria bancrofti
}}
| This area was generated with Dilib version V0.6.31. |  |